The liver, gut and cycle framework behind our approach to estrogen metabolism.
We look at estrogen production, progesterone and ovulation, liver processing, bile, bowel function and recovery together. This guide explains those connections and the tools considered within the framework, without assuming one symptom proves where the problem sits.
01 of 08
Start with the cycle and the pattern
We distinguish an absolute elevation in estrogen from a relative imbalance involving progesterone. That difference matters. The same instruction to “lower estrogen” does not fit every person who reports PMS, breast tenderness, fluid retention or cycle changes.
We want to know when symptoms occur, whether ovulation is occurring, what the cycle has been doing and what changed before the pattern began. Coming off contraception, postpartum changes, perimenopause, food restriction and disrupted recovery provide different contexts.
The purpose of looking at clearance is to include the systems that process and eliminate hormones. It does not mean that every symptom is caused by a blocked pathway. We connect the cycle history with the wider MARCH picture before selecting support.
02 of 08
The three-phase clearance framework
Phase 1: modification. Liver enzymes modify estrogen into metabolites. This includes hydroxylation and the different metabolite pathways.
Three phases of clearance
01
Modify
Phase 1 · liver enzymes modify estrogen.
02
Conjugate
Phase 2 · methylation, glucuronidation and sulfation.
03
Eliminate
Phase 3 · bile, bowel function and elimination.
Phase 2: conjugation. Processes including methylation, glucuronidation and sulfation modify compounds for further handling and elimination. We review protein intake and relevant nutrient cofactors at this stage.
Phase 3: elimination. Bile and the intestine participate in the handling and excretion of estrogen metabolites. Gut bacterial enzymes, including beta-glucuronidase, can affect deconjugation and recirculation.
This explains why our estrogen work includes digestion and bowel function. A hormone-focused plan can overlook those systems if it starts and ends with one blood result. The practical aim is to understand the whole pathway and select support for the part of the case that actually needs it.
03 of 08
Five areas we review
Liver processing: food intake, alcohol, medication, relevant results and the demands placed on the person. A single low liver-enzyme value does not locate a specific clearance failure.
Gut function: digestion, food tolerance, previous infections or treatment, and the wider intestinal picture. We consider the estrobolome and beta-glucuronidase; bloating alone does not measure either.
Bile: the relationship between liver output, fat digestion and elimination. We select bile support according to the wider picture.
Bowel function: stool consistency, ease of passage, completeness and the person’s usual pattern. The aim is comfortable, regular elimination rather than chasing a compulsory number of bowel movements.
Ovulation and progesterone: hormone values must be read in relation to the cycle. The timing, units and formulation of any hormone treatment matter.
04 of 08
The raw-carrot practice
One simple food preparation is a medium raw carrot, shredded or grated, dressed with olive or coconut oil and a little salt.
The raw-carrot practice
01
Prepare
One medium raw carrot, shredded or grated.
02
Dress
Olive or coconut oil and a little salt.
03
Keep in context
A food practice, not a hormone treatment.
The aim is to support fibre intake and the gut’s role in elimination. A carrot is not a treatment for a hormone disorder or a promise that your estrogen result will change.
If you enjoy it and tolerate it, it can be one food option within the plan. Raw vegetables do not suit every gut phase or every person. The gut framework takes tolerance into account rather than forcing the same food on everyone.
The original preparation also included apple cider vinegar. It is not necessary to make the carrot a usable food, and adding an acidic product is a separate tolerance decision.
05 of 08
What the supplement framework is trying to address
We consider DIM and cruciferous compounds in relation to estrogen-metabolite handling. They are not the entire clearance plan, and we distinguish a low-estrogen picture from one in which DIM is considered.
We consider calcium-D-glucarate in relation to glucuronidation and gut deconjugation, TUDCA and milk thistle for liver-and-bile support, and NAC as a glutathione precursor. B vitamins are considered in relation to methylation and nutrient status.
We may also consider quercetin when inflammation or histamine is part of the picture, alongside individually selected nutritional support. It is not a direction to buy every item or combine them without checking the person’s medication, circumstances and phase.
Our sequence asks which part of the picture needs support first and what response would justify continuing. A long list without that reasoning is not an individual protocol.
06 of 08
Where progesterone fits
Progesterone is part of the cycle and signalling discussion in our framework. We consider ovulation, cycle timing, sleep, symptoms and the relevant results together rather than treating a single estrogen value as the whole case.
Formulation, indication, pregnancy possibility and prescribing oversight matter.
Supporting the underlying foundation and making a hormone-treatment decision are separate steps. Nutrition, digestion and recovery remain part of coaching; hormone use is a separate, individual decision. A calendar alone does not establish that a person needs progesterone.
07 of 08
Food and recovery within the framework
We emphasise enough protein, tolerated fibre, cruciferous vegetables, sulfur-containing foods and fats that fit the individual’s digestion. Examples include eggs, fish or meat where suitable, vegetables such as broccoli and cabbage, and olive oil used in ordinary meals.
Build meals around the foundation
01
Protein
Enough to support your needs.
02
Tolerated fibre
Adapted to digestion and bowel function.
03
Vegetables
Cruciferous and sulfur-containing foods.
04
Suitable fats
Choices that fit your digestion.
We also review alcohol, highly processed food, cooking fats and food-contact exposures. They should not become an expanding list of foods someone is frightened to eat.
Gut tolerance and phase matter. Fermented foods, raw vegetables and increased fibre are not interchangeable or compulsory. Someone struggling to eat enough needs a manageable plan before another layer of restriction.
08 of 08
Turn the framework into a daily plan
Morning: eat a substantial breakfast that fits your needs and record relevant cycle information. If temperature tracking is part of your agreed plan, use it consistently as one observation rather than a stand-alone diagnosis.
Meals: include protein and tolerated plant foods. Place any selected support at its agreed time so it does not compete with medication instructions or turn meals into a collection of supplements.
Across the day: note bowel comfort, symptom timing and how food is tolerated. Choose the food practices that fit your gut rather than forcing every recommendation from a list.
Evening: protect recovery and follow the individual plan. Review changes across the cycle, not just from one difficult day. The purpose of tracking is to decide what to keep, adjust or reconsider.
Want the cycle, digestion and bloodwork picture connected into one plan? We use MARCH to decide what needs attention first and support the routine through regular coaching reviews.